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Objective:To encourage the innovation of medical science and technology, regulate the Investigator Initiated Clinical Trials (IIT), this paper analyzed the problems faced by the management of human genetic resources in medical institution, and the corresponding management measures.Methods:Existing problems of human genetic resource management in IIT were discussed and summarized, taking into consideration of regulatory requirements and daily practices in the hospital.Results:Problems identified include imperfect supervision mechanism, incomplete policy interpretation, insufficient understanding of human genetic resources management policies by researchers, and how to support innovation with human gentic resources and so on.Conclusions:Medical institutions should establish and improve the supervision system and strengthen the whole process management of IIT. Accurately interpret regulatory requirements to improve application efficiency. Improve researchers′ recognition of human genetic resources to avoid omission and misrepresentation. Build a biobank to encourage legal and compliant use of human genetic resources to carry out high-quality IIT.
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Objective To strengthen human genetic resource management in clinical trials.Methods This article analyzes the common problems in the process of reviewing human genetic resources application by the drug clinical trial institute in our hospital,and proposes solutions for solving the problems.Results Common questions are also the key points for future review of human genetic resources applications,including the collection of sample and consistency with clinical trial plan,ethical review and informed consent,intellectual property rights etc.Conclusions Strictly reviewing applications of human genetic resources,as well as strengthen the management of human genetic resources in clinical trials,are not only make traceability of human genetic resources traceable,but also have important significance for the authenticity and scientific validity of trial results.
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Objective Base on the requirements of national science and technology system reform,to optimize the information system of scientific research management in hospital,improve the level of scientific research management and service.Methods According to the requirements of the national science and technology system reform and the current situation of our hospital,Peking University People's Hospital had formulated and implemented the optimization scheme of the information system of scientific research management.The questionnaire survey was used to understand the optimization effect of information system.Results The hospital had established a whole process coverage and real-time dynamic information system of scientific research management,which improved the efficiency and quality of scientific research management.The survey results showed that the hospital users have a good evaluation of the information system,and the system construction has a strong advantage in the Beijing district hospitals.Conclusions The whole process and real-time dynamic information system of scientific research management established by the hospital accords with the relevant requirements of national science and technology system reform,and effectively improves the level of scientific research management and service in our hospital.
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Objective To evaluate the research performance based on DEA and to provide the corresponding development measures for medical subjects in hospital.Methods Based on the analysis of medical subjects at Peking University People's Hospital,this paper explored the evaluation index system of medical subjects.The output-oriented DEA was selected and applied in the performance evaluation.Results We figure out that the DEA ratio of every medical subject with the established method in the program of DEAP Version 2.1.Conclusions The method based on DEA can reflect the performance of medical subjects,and the analysis of the evaluation results can provide the management department of hospital with evidences and references for policy making of medical subjects' development.
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Objective To provide helpful experiences for the development,construction,and evaluation of RRP through constructing the evaluation system.Methods The study of literature and comprebensive analysis were employed.Results Putting forward the principle of establishing the evaluation system and finally,attempting to build an evaluation system that specifically aiming at the RRP system.Conclusions The evaluation methods should be updated.
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Objective To explore the establishment and application of scientific research personnel performance evaluation system based on Research Resource Planning (RRP).Methods Establish the index system and weight coefficient of scientific research personnel performance evaluation system by Delphi Method and Analytic Hierarchy Process.The evaluation system is applying for tailored scientific research personnel training according to the analysis of current development status of young researchers.Results Scientific research personnel performance evaluation system,based on the indicators of research capacity,research outcome and research platform is established and applying for personnel training,personnel assessment and incentive policy-making.Conclusions The evaluation system based on RRP can objectively reflect the current situation of the development of scientific research personnel,which plays an important role in promoting the sustainable development of scientific research personnel.
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Objective To summarize the hospital research and development fund achievements in 5 years,continuing to promote innovative management concept.Methods By summarizing the fund's input and output of scientific research during 2006 to 2010,analysis of the effects in the cultivation of medical scientific research personnel and promotion of discipline development in hospital after the implementation of innovative management ideas.Results After the implementation of the innovation process management,output of fund is well.It has played a positive role in promoting to the scientific research personnel and discipline development.Conclusion It should be further promoted of the innovation process management idea,in order to further play the role of seed fund role in talent,discipline development.
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Based on the analysis of the status quo and problems of the management of companyfunded research projects,the feasible management measures are proposed and a standardized management mode for company-funded research projects is established.The establishment and application of the management mode are effective in regulating the supervision and management of those projects,facilitate the implementation of the projects,and optimize the use of research funds.
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It is key for research institutions to ensure the standardized supervision of the progression and fund use of research projects.Peking University People's Hospital designed and applied a whole-process management mode of projects based on information system,which oversaw the conduct and funds management of projects.The application of this mode has significantly promoted the management level of scientific research projects.
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Object To establish and apply an evaluation method based on DEA in NSFC project performance evaluation. Methods Based on the analysis of NSFC projects in Peking University People's Hospital,this paper determined the evaluation index system of NSFC projects.The outputoriented DEA was selected and applied in the performance evaluation.Results We figures out the DEA ratio of every NSFC project with the established method in the program of DEAP Version 2.1.Conclusion The method based on DEA can reflect the performance of NSFC projects,and the evaluation results can provide project managers and the management department of NSFC with evidences and references to make polices for project management.
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Fine management of scientific research funds is an important support for implementation of scientific research projects and promotion of scientific researches in hospital.In order to ensure effective usage of scientific research funds and sustainable development of scientific research,Peking University People's Hospital has laid much stress on the management of scientific research funds,and explored the methods and measures for fine management of scientific research funds.
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Objective To investigate the expression of preferentially expressed antigen of melanoma (PRAME) gene in acute leukemia and its clinical significance.Methods PRAME mRNA levels were detected in bone marrow samples from 119 cases with acute leukemia (out of which 97 cases were acute myeloid leukemia, 22 cases were acute lymphocytic leukemia) by TaqMan based real-time quantitative PCR methods and compared it with the expression of FLT3 gene. Results PRAME mRNA was revealed in 50 of 97 AML (51.5 %), 8 of 22 ALL (36.4 %), and 5 patients were found little expression of PRAME in 11 healthy subjects and 17 non-blood disease patients. However, 17 AML, and 3 ALL patients with PRAME expression had no detectable FLT3. 9 patients with the expression of both PRAME and FLT3 genes were monitored in short follow-up. The lower level of PRAME was detected in all patients when they were in complete remission (CR) after chemotherapy. Conclusion PRAME gene was expressed in acute leukemia patients and will hopefully become a symbolic gene during the course of diagnosis and treatment in acute leukemia.
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With the improvement in new drug clinical trials, our hospital has participated in more and more international multi-center clinical trials. Meanwhile, problems arise in carrying out these trials.We here analyzed these problems and put forward some measures for improvement.
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Since Peking University People's Hospital Research and Development Funds were founded as "Seed Funds" in 2006, its management concept has been developing. During the development, the policy-oriented service replaced the policy-based single service. The three-dimensional service system was formed. As the result, the scientific research outputs increased annually with good development condition.
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The scientific research achievements and possible impact factors were analyzed statistically in the hospital during the past 10 years,especially in 2007,and the analysis result showed the development trends of the scientific research and impact factors of rewards.Also,to improve medical scientific research and its management level,the author proposed the related countermeasures and suggestions in this artiele.
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This article explored the open mode of the scientific research management and discussed its applying effectiveness in Peking University People's Hospital.The dual character of the open mode was raised innovatively which was summarized as resource sharing and constraint sharing.Our scientific research management has developed because of promotion and implement of the open system and creative methods,hich contained the dual character.
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The talent cultivation and echelon construction are the embodiment of core competition and the source of sustainable development in the hospitaI.In order to expedite the talent cuhivation based on the talent database an individuation mode of talent cuhivation was established in Peking University People's Hospital.Following this mode the individuation cultivation of talents and echelon construction were achieved,consequently,the scientific research team would be expected to form and develop.
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This article summarized the management status of scientific research fund of our hospital. It focused on the whole process management which included the establishment,application and permission of the fund,supervision and tracking of the granted projects.All the management process was dealt with the management mode including standard management,scientific management and tracking management.Some effective experiences were obtained from the whole process management.
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Full-process management pattern is applied to the management of the research and development funds in Peking University People's Hospital,which covers the full process of a subject including the subject application,evaluation of the subject selection,mid-term evaluation and evaluation after the SUbject completion.In order to guarantee the objectivity and fairness of subject evaluation.based on visual analogue scale a new evaluation method was first established and flint used in the SUbject evaluation of the research and development funds in Peking University People's Hospital.The comparative analysis of resuits from the two evaluation methods,indicated that the evaluation method based on visual analogue scale eould be used in subject evaluation due to the same credibility of evaluation, and it Was better as compared with the traditional likea-type scale.
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<p><b>BACKGROUND</b>Melanoma antigen genes (MAGE) are tumor specific genes. The aim of this study is to explore the feasibility of MAGE genes detection as a diagnostic method for malignant pleural effusion.</p><p><b>METHODS</b>The expression of MAGE-1, -2, -3 and -4 mRNA was detected in 18 benign and 22 malignant pleural effusion samples by RT-PCR.</p><p><b>RESULTS</b>No MAGE gene expressed in the 18 cases of benign pleural effusion. Out of the 22 cases of malignant pleural effusion, 8 cases were positive by cytological examination, who all showed positive expression of MAGA genes; in the other 14 patients who were positive by pleural biopsy but negative by cytological examination, 11 cases showed positive expression of MAGE genes in both the pleural effusion and pleura samples, while the other 3 cases showed negative MAGE expression in both the pleural effusion and pleura samples.</p><p><b>CONCLUSIONS</b>Detection of MAGE genes in pleural effusion may be an effective method in the differential diagnosis of benign and malignant pleural effusion.</p>